2CN5

Crystal structure of human Chk2 in complex with ADP

2CN5 の概要

• エントリーDOI: 10.2210/pdb2cn5/pdb
• 関連するPDBエントリー: 1GXC 2CN8
• 分子名称: SERINE/THREONINE-PROTEIN KINASE CHK2, CHLORIDE ION, MAGNESIUM ION, ... (6 entities in total)
• 機能のキーワード: transferase, kinase, kinase domain, checkpoint, cancer, tumour suppressor, chek2, chk2, cds1, rad53, phosphorylation, activation segment, li-fraumeni syndrome, atp-binding, cell cycle, disease mutation, magnesium, metal-binding, nuclear protein, nucleotide-binding, proto-oncogene, serine/threonine-protein kinase
• 由来する生物種: HOMO SAPIENS (HUMAN)
• 細胞内の位置: Isoform 2: Nucleus. Isoform 4: Nucleus. Isoform 7: Nucleus. Isoform 9: Nucleus. Isoform 12: Nucleus. Nucleus, PML body: O96017
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 37685.11

構造登録者

Oliver, A.W.,Pearl, L.H. (登録日: 2006-05-18, 公開日: 2006-06-28, 最終更新日: 2023-12-13)

• 主引用文献: Oliver, A.W.,Paul, A.,Boxall, K.J.,Barrie, S.E.,Aherne, G.W.,Garrett, M.D.,Mittnacht, S.,Pearl, L.H.; Trans-Activation of the DNA-Damage Signalling Protein Kinase Chk2 by T-Loop Exchange; Embo J., 25:3179-, 2006; PubMed: 16794575; DOI: 10.1038/SJ.EMBOJ.7601209

実験手法

X-RAY DIFFRACTION (2.25 Å)