2CL8

Dectin-1 in complex with beta-glucan

2CL8 の概要

• エントリーDOI: 10.2210/pdb2cl8/pdb
• 関連するPDBエントリー: 2BPD 2BPE 2BPH
• 分子名称: DECTIN-1, beta-D-glucopyranose-(1-3)-beta-D-glucopyranose-(1-3)-beta-D-glucopyranose, CALCIUM ION, ... (5 entities in total)
• 機能のキーワード: carbohydrate, fungal recognition, ctld, receptor, dectin-1, laminarin, beta-glucan, c-type lectin-like domain
• 由来する生物種: MUS MUSCULUS (MOUSE)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 32918.09

構造登録者

Brown, J.,O'Callaghan, C.A.,Marshall, A.S.J.,Gilbert, R.J.C.,Siebold, C.,Gordon, S.,Brown, G.D.,Jones, E.Y. (登録日: 2006-04-26, 公開日: 2007-05-15, 最終更新日: 2024-11-06)

主引用文献

Brown, J.,O'Callaghan, C.A.,Marshall, A.S.J.,Gilbert, R.J.C.,Siebold, C.,Gordon, S.,Brown, G.D.,Jones, E.Y.
Structure of the Fungal Beta-Glucan-Binding Immune Receptor Dectin-1: Implications for Function.
Protein Sci., 16:1042-, 2007

PubMed Abstract: The murine molecule dectin-1 (known as the beta-glucan receptor in humans) is an immune cell surface receptor implicated in the immunological defense against fungal pathogens. Sequence analysis has indicated that the dectin-1 extracellular domain is a C-type lectin-like domain, and functional studies have established that it binds fungal beta-glucans. We report several dectin-1 crystal structures, including a high-resolution structure and a 2.8 angstroms resolution structure in which a short soaked natural beta-glucan is trapped in the crystal lattice. In vitro characterization of dectin-1 in the presence of its natural ligand indicates higher-order complex formation between dectin-1 and beta-glucans. These combined structural and biophysical data considerably extend the current knowledge of dectin-1 structure and function, and suggest potential mechanisms of defense against fungal pathogens.

PubMed: 17473009
DOI: 10.1110/PS.072791207

実験手法

X-RAY DIFFRACTION (2.8 Å)