2CB5

HUMAN BLEOMYCIN HYDROLASE, C73S/DELE455 MUTANT

2CB5 の概要

• エントリーDOI: 10.2210/pdb2cb5/pdb
• 関連するPDBエントリー: 1CB5
• 分子名称: PROTEIN (BLEOMYCIN HYDROLASE) (2 entities in total)
• 機能のキーワード: hydrolase, aminopeptidase, cysteine protease, self-compartmentalizing, bleomycin, cylinase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: Q13867
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 104655.34

構造登録者

O'Farrell, P.A.,Gonzalez, F.,Zheng, W.,Johnston, S.A.,Joshua-Tor, L. (登録日: 1999-03-02, 公開日: 2000-03-06, 最終更新日: 2023-08-23)

主引用文献

O'Farrell, P.A.,Gonzalez, F.,Zheng, W.,Johnston, S.A.,Joshua-Tor, L.
Crystal structure of human bleomycin hydrolase, a self-compartmentalizing cysteine protease.
Structure Fold.Des., 7:619-627, 1999

PubMed Abstract: Bleomycin hydrolase (BH) is a cysteine protease that is found in all tissues in mammals as well as in many other eukaryotes and prokaryotes. Although its conserved cellular function is as yet unknown, human bleomycin hydrolase (hBH) has clinical significance in that it is thought to be the major cause of tumor cell resistance to bleomycin chemotherapy. In addition, it has been reported that an allelic variant of hBH is genetically linked to Alzheimer's disease.

PubMed: 10404591
DOI: 10.1016/S0969-2126(99)80083-5

実験手法

X-RAY DIFFRACTION (1.85 Å)