2CB2

Sulfur Oxygenase Reductase from Acidianus Ambivalens

2CB2 の概要

• エントリーDOI: 10.2210/pdb2cb2/pdb
• 分子名称: SULFUR OXYGENASE REDUCTASE, FE (III) ION (3 entities in total)
• 機能のキーワード: oxidoreductase, sulfur oxygenase reductase, mononuclear non-heme iron, biogeochemical sulfur cycle, extremophile, thermophilic, acidophilic, cysteine persulphide, icosatetramer, proto- organelle, nano-structure, compartmentalization, 2-his-1- carboxylate facial triad, archaea, metal-binding
• 由来する生物種: ACIDIANUS AMBIVALENS
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 218897.26

構造登録者

Urich, T.,Gomes, C.M.,Kletzin, A.,Frazao, C. (登録日: 2005-12-28, 公開日: 2006-02-24, 最終更新日: 2024-11-13)

主引用文献

Urich, T.,Gomes, C.M.,Kletzin, A.,Frazao, C.
X-Ray Structure of a Self-Compartmentalizing Sulfur Cycle Metalloenzyme
Science, 311:996-, 2006

PubMed Abstract: Numerous microorganisms oxidize sulfur for energy conservation and contribute to the global biogeochemical sulfur cycle. We have determined the 1.7 angstrom-resolution structure of the sulfur oxygenase reductase from the thermoacidophilic archaeon Acidianus ambivalens, which catalyzes an oxygen-dependent disproportionation of elemental sulfur. Twenty-four monomers form a large hollow sphere enclosing a positively charged nanocompartment. Apolar channels provide access for linear sulfur species. A cysteine persulfide and a low-potential mononuclear non-heme iron site ligated by a 2-His-1-carboxylate facial triad in a pocket of each subunit constitute the active sites, accessible from the inside of the sphere. The iron is likely the site of both sulfur oxidation and sulfur reduction.

PubMed: 16484493
DOI: 10.1126/SCIENCE.1120306

実験手法

X-RAY DIFFRACTION (1.7 Å)