2CAG

CATALASE COMPOUND II

2CAG の概要

• エントリーDOI: 10.2210/pdb2cag/pdb
• 分子名称: CATALASE COMPOUND II, PROTOPORPHYRIN IX CONTAINING FE (3 entities in total)
• 機能のキーワード: oxidoreductase (h2o2 acceptor), peroxidase, iron, heme, hydrogen peroxide, nadp
• 由来する生物種: Proteus mirabilis
• 細胞内の位置: Cytoplasm: P42321
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 56342.83

構造登録者

Gouet, P.,Jouve, H.M.,Hajdu, J. (登録日: 1996-06-12, 公開日: 1996-12-07, 最終更新日: 2024-10-23)

主引用文献

Gouet, P.,Jouve, H.M.,Williams, P.A.,Andersson, I.,Andreoletti, P.,Nussaume, L.,Hajdu, J.
Ferryl intermediates of catalase captured by time-resolved Weissenberg crystallography and UV-VIS spectroscopy.
Nat.Struct.Biol., 3:951-956, 1996

PubMed Abstract: Various enzymes use semi-stable ferryl intermediates and free radicals during their catalytic cycle, amongst them haem catalases. Structures for two transient intermediates (compounds I and II) of the NADPH-dependent catalase from Proteus mirabilis (PMC) have been determined by time-resolved X-ray crystallography and single crystal microspectrophotometry. The results show the formation and transformation of the ferryl group in the haem, and the unexpected binding of an anion during this reaction at a site distant from the haem.

PubMed: 8901874
DOI: 10.1038/nsb1196-951

実験手法

X-RAY DIFFRACTION (2.7 Å)