2C7H

Solution NMR structure of the DWNN domain from human RBBP6

2C7H の概要

• エントリーDOI: 10.2210/pdb2c7h/pdb
• 分子名称: RETINOBLASTOMA-BINDING PROTEIN 6, ISOFORM 3 (1 entity in total)
• 機能のキーワード: rbbp6, p53-associated, mrna processing, splicing-associated, oesophageal cancer, ubiquitin-like protein
• 由来する生物種: HOMO SAPIENS (HUMAN)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 9544.00

構造登録者

Pugh, D.J.R.,Ab, E.,Faro, A.,Lutya, P.T.,Hoffmann, E.,Rees, D.J.G. (登録日: 2005-11-24, 公開日: 2006-01-19, 最終更新日: 2024-05-15)

主引用文献

Pugh, D.J.R.,Ab, E.,Faro, A.,Lutya, P.T.,Hoffmann, E.,Rees, D.J.G.
Dwnn, a Novel Ubiquitin-Like Domain, Implicates Rbbp6 in Mrna Processing and Ubiquitin-Like Pathways
Bmc Struct.Biol., 6:1-, 2006

PubMed Abstract: RBBP6 is a 250 kDa splicing-associated protein that has been identified as an E3 ligase due to the presence of a RING finger domain. In humans and mice it interacts with both p53 and Rb, and plays a role in the induction of apoptosis and regulation of the cell cycle. RBBP6 has recently been shown to be highly up-regulated in oesophageal cancer, and to be a promising target for immunotherapy against the disease.

PubMed: 16396680
DOI: 10.1186/1472-6807-6-1

実験手法

SOLUTION NMR