2C65

MAO inhibition by rasagiline analogues

2C65 の概要

• エントリーDOI: 10.2210/pdb2c65/pdb
• 関連するPDBエントリー: 1GOS 1H8R 1OJ9 1OJA 1OJB 1OJC 1OJD 1S2Q 1S2Y 1S3B 1S3E 2BK3 2BK4 2BK5 2BYB 2C64 2C66 2C67
• 分子名称: AMINE OXIDASE [FLAVIN-CONTAINING] B, FLAVIN-ADENINE DINUCLEOTIDE, (1R)-4-({[ETHYL(METHYL)AMINO]CARBONYL}OXY)-N-METHYL-N-[(1E)-PROP-2-EN-1-YLIDENE]INDAN-1-AMINIUM, ... (4 entities in total)
• 機能のキーワード: oxidoreductase, enantioselectivity, fad, flavin, flavoprotein, human monoamine oxidase, inhibitor binding, mitochondrion, rasagiline, transmembrane, parkinson, acetylation
• 由来する生物種: HOMO SAPIENS (HUMAN)
• 細胞内の位置: Mitochondrion outer membrane; Single-pass type IV membrane protein; Cytoplasmic side: P27338
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 119821.31

構造登録者

Binda, C.,Hubalek, F.,Li, M.,Herzig, Y.,Sterling, J.,Edmondson, D.E.,Mattevi, A. (登録日: 2005-11-07, 公開日: 2006-01-04, 最終更新日: 2023-12-13)

• 主引用文献: Binda, C.,Hubalek, F.,Li, M.,Herzig, Y.,Sterling, J.,Edmondson, D.E.,Mattevi, A.; Binding of Rasagiline-Related Inhibitors to Human Monoamine Oxidases: A Kinetic and Crystallographic Analysis.; J.Med.Chem., 48:8148-, 2005; PubMed: 16366596; DOI: 10.1021/JM0506266

実験手法

X-RAY DIFFRACTION (1.7 Å)