2C5Q
Crystal structure of yeast YER010Cp
Summary for 2C5Q
| Entry DOI | 10.2210/pdb2c5q/pdb |
| Descriptor | RRAA-LIKE PROTEIN YER010C, 1,2-ETHANEDIOL (3 entities in total) |
| Functional Keywords | structural genomics, unknown function, pseudo-knot, rraa |
| Biological source | SACCHAROMYCES CEREVISIAE (BAKER'S YEAST) |
| Total number of polymer chains | 6 |
| Total formula weight | 159766.17 |
| Authors | Leulliot, N.,Quevillon-Cheruel, S.,Graille, M.,Schiltz, M.,Blondeau, K.,Janin, J.,van Tilbeurgh, H. (deposition date: 2005-10-31, release date: 2005-11-14, Last modification date: 2024-10-09) |
| Primary citation | Leulliot, N.,Quevillon-Cheruel, S.,Graille, M.,Schiltz, M.,Blondeau, K.,Janin, J.,Van Tilbeurgh, H. Crystal Structure of Yeast Yer010Cp, a Knotable Member of the Rraa Protein Family. Protein Sci., 14:2751-, 2005 Cited by PubMed Abstract: We present here the structure of Yer010c protein of unknown function, solved by Multiple Anomalous Diffraction and revealing a common fold and oligomerization state with proteins of the regulator of ribonuclease activity A (RraA) family. In Escherichia coli, RraA has been shown to regulate the activity of ribonuclease E by direct interaction. The absence of ribonuclease E in yeast suggests a different function for this family member in this organism. Yer010cp has a few supplementary secondary structure elements and a deep pseudo-knot at the heart of the protein core. A tunnel at the interface between two monomers, lined with conserved charged residues, has unassigned residual electron density and may constitute an active site for a yet unknown activity. PubMed: 16195557DOI: 10.1110/PS.051684005 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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