2C5Q

Crystal structure of yeast YER010Cp

2C5Q の概要

• エントリーDOI: 10.2210/pdb2c5q/pdb
• 分子名称: RRAA-LIKE PROTEIN YER010C, 1,2-ETHANEDIOL (3 entities in total)
• 機能のキーワード: structural genomics, unknown function, pseudo-knot, rraa
• 由来する生物種: SACCHAROMYCES CEREVISIAE (BAKER'S YEAST)
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 159766.17

構造登録者

Leulliot, N.,Quevillon-Cheruel, S.,Graille, M.,Schiltz, M.,Blondeau, K.,Janin, J.,van Tilbeurgh, H. (登録日: 2005-10-31, 公開日: 2005-11-14, 最終更新日: 2024-10-09)

主引用文献

Leulliot, N.,Quevillon-Cheruel, S.,Graille, M.,Schiltz, M.,Blondeau, K.,Janin, J.,Van Tilbeurgh, H.
Crystal Structure of Yeast Yer010Cp, a Knotable Member of the Rraa Protein Family.
Protein Sci., 14:2751-, 2005

PubMed Abstract: We present here the structure of Yer010c protein of unknown function, solved by Multiple Anomalous Diffraction and revealing a common fold and oligomerization state with proteins of the regulator of ribonuclease activity A (RraA) family. In Escherichia coli, RraA has been shown to regulate the activity of ribonuclease E by direct interaction. The absence of ribonuclease E in yeast suggests a different function for this family member in this organism. Yer010cp has a few supplementary secondary structure elements and a deep pseudo-knot at the heart of the protein core. A tunnel at the interface between two monomers, lined with conserved charged residues, has unassigned residual electron density and may constitute an active site for a yet unknown activity.

PubMed: 16195557
DOI: 10.1110/PS.051684005

実験手法

X-RAY DIFFRACTION (1.7 Å)