2C0L

TPR DOMAIN OF HUMAN PEX5P IN COMPLEX WITH HUMAN MSCP2

2C0L の概要

• エントリーDOI: 10.2210/pdb2c0l/pdb
• 関連するPDBエントリー: 1FCH 1QND
• 分子名称: PEROXISOMAL TARGETING SIGNAL 1 RECEPTOR, NONSPECIFIC LIPID-TRANSFER PROTEIN (3 entities in total)
• 機能のキーワード: transport protein/receptor, tpr repeat, transport, import receptor complex, peroxisome, disease mutation, protein transport, zellweger syndrome, alternative initiation, lipid transport, lipid-binding, mitochondrion, transit peptide, transport protein-receptor complex
• 由来する生物種: HOMO SAPIENS (HUMAN); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 46696.17

構造登録者

Stanley, W.A.,Kursula, P.,Wilmanns, M. (登録日: 2005-09-05, 公開日: 2006-11-15, 最終更新日: 2024-05-08)

主引用文献

Stanley, W.A.,Filipp, F.V.,Kursula, P.,Schuller, N.,Erdmann, R.,Schliebs, W.,Sattler, M.,Wilmanns, M.
Recognition of a Functional Peroxisome Type 1 Target by the Dynamic Import Receptor Pex5P.
Mol.Cell, 24:653-, 2006

PubMed Abstract: Peroxisomes require the translocation of folded and functional target proteins of various sizes across the peroxisomal membrane. We have investigated the structure and function of the principal import receptor Pex5p, which recognizes targets bearing a C-terminal peroxisomal targeting signal type 1. Crystal structures of the receptor in the presence and absence of a peroxisomal target, sterol carrier protein 2, reveal major structural changes from an open, snail-like conformation into a closed, circular conformation. These changes are caused by a long loop C terminal to the 7-fold tetratricopeptide repeat segments. Mutations in residues of this loop lead to defects in peroxisomal import in human fibroblasts. The structure of the receptor/cargo complex demonstrates that the primary receptor-binding site of the cargo is structurally and topologically autonomous, enabling the cargo to retain its native structure and function.

PubMed: 17157249
DOI: 10.1016/J.MOLCEL.2006.10.024

実験手法

X-RAY DIFFRACTION (2.3 Å)