2BPX

HIV-1 protease-inhibitor complex

Summary for 2BPX

Entry DOI	10.2210/pdb2bpx/pdb
Descriptor	HIV-1 PROTEASE, N-[2(R)-HYDROXY-1(S)-INDANYL]-5-[(2(S)-TERTIARY BUTYLAMINOCARBONYL)-4(3-PYRIDYLMETHYL)PIPERAZINO]-4(S)-HYDROXY-2(R)-PHENYLMETHYLPENTANAMIDE (3 entities in total)
Functional Keywords	acid protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Human immunodeficiency virus 1
Cellular location	Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P04587
Total number of polymer chains	2
Total formula weight	22221.30
Authors	Munshi, S.,Chen, Z. (deposition date: 1998-01-22, release date: 1999-02-23, Last modification date: 2024-02-14)
Primary citation	Munshi, S.,Chen, Z.,Li, Y.,Olsen, D.B.,Fraley, M.E.,Hungate, R.W.,Kuo, L.C. Rapid X-ray diffraction analysis of HIV-1 protease-inhibitor complexes: inhibitor exchange in single crystals of the bound enzyme. Acta Crystallogr.,Sect.D, 54:1053-1060, 1998 Cited by PubMed: 9757136 DOI: 10.1107/S0907444998003588 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation