2BPW

HIV-1 protease-inhibitor complex

2BPW の概要

• エントリーDOI: 10.2210/pdb2bpw/pdb
• 分子名称: HIV-1 PROTEASE, 1-[2-HYDROXY-4-(2-HYDROXY-5-METHYL-CYCLOPENTYLCARBAMOYL)5-PHENYL-PENTYL]-4-(3-PYRIDIN-3-YL-PROPIONYL)-PIPERAZINE-2-CARB OXYLIC ACID TERT-BUTYLAMIDE (3 entities in total)
• 機能のキーワード: acid protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Human immunodeficiency virus 1
• 細胞内の位置: Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P04587
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 22229.32

構造登録者

Munshi, S.,Chen, Z. (登録日: 1998-01-22, 公開日: 1999-02-23, 最終更新日: 2024-02-14)

• 主引用文献: Munshi, S.,Chen, Z.,Li, Y.,Olsen, D.B.,Fraley, M.E.,Hungate, R.W.,Kuo, L.C.; Rapid X-ray diffraction analysis of HIV-1 protease-inhibitor complexes: inhibitor exchange in single crystals of the bound enzyme.; Acta Crystallogr.,Sect.D, 54:1053-1060, 1998; PubMed: 9757136; DOI: 10.1107/S0907444998003588

実験手法

X-RAY DIFFRACTION (2.8 Å)