2BPI

Structure of Iron dependent superoxide dismutase from P. falciparum.

2BPI の概要

• エントリーDOI: 10.2210/pdb2bpi/pdb
• 分子名称: FE-SUPEROXIDE DISMUTASE, FE (III) ION (3 entities in total)
• 機能のキーワード: dismutase, oxidoreductase, metal-binding
• 由来する生物種: PLASMODIUM FALCIPARUM
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 47775.17

構造登録者

Boucher, I.W.,Brannigan, J.,Wilkinson, A.J.,Brzozowski, M. (登録日: 2005-04-20, 公開日: 2006-10-11, 最終更新日: 2023-12-13)

主引用文献

Boucher, I.W.,Brzozowski, A.M.,Brannigan, J.A.,Schnick, C.,Smith, D.J.,Kyes, S.A.,Wilkinson, A.J.
The Crystal Structure of Superoxide Dismutase from Plasmodium Falciparum.
Bmc Struct.Biol., 6:20-, 2006

PubMed Abstract: Superoxide dismutases (SODs) are important enzymes in defence against oxidative stress. In Plasmodium falciparum, they may be expected to have special significance since part of the parasite life cycle is spent in red blood cells where the formation of reactive oxygen species is likely to be promoted by the products of haemoglobin breakdown. Thus, inhibitors of P. falciparum SODs have potential as anti-malarial compounds. As a step towards their development we have determined the crystal structure of the parasite's cytosolic iron superoxide dismutase.

PubMed: 17020617
DOI: 10.1186/1472-6807-6-20

実験手法

X-RAY DIFFRACTION (2.52 Å)