2BAT

THE STRUCTURE OF THE COMPLEX BETWEEN INFLUENZA VIRUS NEURAMINIDASE AND SIALIC ACID, THE VIRAL RECEPTOR

2BAT の概要

• エントリーDOI: 10.2210/pdb2bat/pdb
• 関連するPDBエントリー: 1NN2
• 分子名称: NEURAMINIDASE N2, 2-acetamido-2-deoxy-4-O-sulfo-alpha-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
• 機能のキーワード: hydrolase(o-glycosyl)
• 由来する生物種: Influenza A virus (A/Tokyo/3/1967(H2N2))
• 細胞内の位置: Virion membrane (By similarity): P06820
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 46386.03

構造登録者

Varghese, J.N.,Colman, P.M. (登録日: 1992-08-10, 公開日: 1994-01-31, 最終更新日: 2024-11-20)

主引用文献

Varghese, J.N.,McKimm-Breschkin, J.L.,Caldwell, J.B.,Kortt, A.A.,Colman, P.M.
The structure of the complex between influenza virus neuraminidase and sialic acid, the viral receptor.
Proteins, 14:327-332, 1992

PubMed Abstract: Crystallographic studies of neuraminidase-sialic acid complexes indicate that sialic acid is distorted on binding the enzyme. Three arginine residues on the enzyme interact with the carboxylate group of the sugar which is observed to be equatorial to the saccharide ring as a consequence of its distorted geometry. The glycosidic oxygen is positioned within hydrogen-bonding distance of Asp-151, implicating this residue in catalysis.

PubMed: 1438172
DOI: 10.1002/prot.340140302

実験手法

X-RAY DIFFRACTION (2 Å)