2BAN

Crystal structure of HIV-1 reverse transcriptase (RT) in complex with JANSSEN-R157208

2BAN の概要

• エントリーDOI: 10.2210/pdb2ban/pdb
• 関連するPDBエントリー: 1S6P 1S6Q 1SV5 2B5J 2BE2
• 分子名称: Reverse transcriptase P66 subunit, Reverse transcriptase P51 subunit, MANGANESE (II) ION, ... (5 entities in total)
• 機能のキーワード: aids, hiv, drug design, reverse transcriptase, rt, protein-inhibitor complex, transferase
• 由来する生物種: Human immunodeficiency virus 1; 詳細
• 細胞内の位置: Gag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03366 P03366
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 115166.11

構造登録者

Das, K.,Arnold, E. (登録日: 2005-10-14, 公開日: 2005-12-06, 最終更新日: 2023-08-23)

• 主引用文献: Himmel, D.M.,Das, K.,Clark Jr., A.D.,Hughes, S.H.,Benjahad, A.,Oumouch, S.,Guillemont, J.,Coupa, S.,Poncelet, A.,Csoka, I.,Meyer, C.,Andries, K.,Nguyen, C.H.,Grierson, D.S.,Arnold, E.; Crystal Structures for HIV-1 Reverse Transcriptase in Complexes with Three Pyridinone Derivatives: A New Class of Non-Nucleoside Inhibitors Effective against a Broad Range of Drug-Resistant Strains.; J.Med.Chem., 48:7582-7591, 2005; PubMed: 16302798; DOI: 10.1021/jm0500323

実験手法

X-RAY DIFFRACTION (2.95 Å)