2BAI
The Zinc finger domain of Mengovirus Leader polypeptide
Summary for 2BAI
| Entry DOI | 10.2210/pdb2bai/pdb |
| NMR Information | BMRB: 6863 |
| Descriptor | Genome polyprotein, ZINC ION (2 entities in total) |
| Functional Keywords | zinc finger domain, virus, viruses, cardiovirus, mengovirus, structural genomics, psi, protein structure initiative, center for eukaryotic structural genomics, cesg, viral protein |
| Biological source | Mengo virus |
| Cellular location | Protein VP2: Virion. Protein VP3: Virion. Protein VP1: Virion: P32540 |
| Total number of polymer chains | 1 |
| Total formula weight | 3789.65 |
| Authors | Cornilescu, C.C.,Porter, F.W.,Qin, Z.,Lee, M.S.,Palmenberg, A.C.,Markley, J.L.,Center for Eukaryotic Structural Genomics (CESG) (deposition date: 2005-10-14, release date: 2006-01-24, Last modification date: 2024-05-22) |
| Primary citation | Cornilescu, C.C.,Porter, F.W.,Zhao, K.Q.,Palmenberg, A.C.,Markley, J.L. NMR structure of the mengovirus Leader protein zinc-finger domain. Febs Lett., 582:896-900, 2008 Cited by PubMed Abstract: The Leader protein is a defining feature of picornaviruses from the Cardiovirus genus. This protein was recently shown to inhibit cellular nucleocytoplasmic transport through an activity mapped to its zinc-binding region. Here we report the three-dimensional solution structure determined by nuclear magnetic resonance (NMR) spectroscopy of this domain (residues 5-28) from mengovirus. The domain forms a CHCC zinc-finger with a fold comprising a beta-hairpin followed by a short alpha-helix that can adopt two different conformations. This structure is divergent from those of other eukaryotic zinc-fingers and instead resembles motifs found in a group of DNA-binding proteins from Archaea. PubMed: 18291103DOI: 10.1016/j.febslet.2008.02.023 PDB entries with the same primary citation |
| Experimental method | SOLUTION NMR |
Structure validation
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