2B5J

Crystal structure of HIV-1 reverse transcriptase (RT) in complex with JANSSEN-R165481

Summary for 2B5J

• Entry DOI: 10.2210/pdb2b5j/pdb
• Descriptor: Reverse transcriptase P66 SUBUNIT, Reverse transcriptase P51 SUBUNIT, MANGANESE (II) ION, ... (5 entities in total)
• Functional Keywords: aids, hiv, drug design, reverse transcriptase, rt, protein-inhibitor complex, transferase
• Biological source: Human immunodeficiency virus 1; More
• Cellular location: Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03366 P03366
• Total number of polymer chains: 2
• Total formula weight: 115243.88

Authors

Himmel, D.H.,Das, K.,Clark Jr., A.D.,Hughes, S.H.,Benjahad, A.,Oumouch, S.,Guillemont, J.,Coupa, S.,Poncelet, A.,Csoka, I.,Meyer, C.,Andries, K.,Mguyen, C.H.,Grierson, D.S.,Arnold, E. (deposition date: 2005-09-28, release date: 2005-12-06, Last modification date: 2023-08-23)

• Primary citation: Himmel, D.M.,Das, K.,Clark Jr., A.D.,Hughes, S.H.,Benjahad, A.,Oumouch, S.,Guillemont, J.,Coupa, S.,Poncelet, A.,Csoka, I.,Meyer, C.,Andries, K.,Nguyen, C.H.,Grierson, D.S.,Arnold, E.; Crystal Structures for HIV-1 Reverse Transcriptase in Complexes with Three Pyridinone Derivatives: A New Class of Non-Nucleoside Inhibitors Effective against a Broad Range of Drug-Resistant Strains.; J.Med.Chem., 48:7582-7591, 2005; PubMed: 16302798; DOI: 10.1021/jm0500323

Experimental method

X-RAY DIFFRACTION (2.9 Å)