2B55

Human cyclin dependent kinase 2 (cdk2) complexed with indenopyraxole DIN-101312

2B55 の概要

• エントリーDOI: 10.2210/pdb2b55/pdb
• 関連するPDBエントリー: 2B52 2B53 2B54
• 分子名称: Cell division protein kinase 2, 2-(4-(AMINOMETHYL)PIPERIDIN-1-YL)-N-(3_CYCLOHEXYL-4-OXO-2,4-DIHYDROINDENO[1,2-C]PYRAZOL-5-YL)ACETAMIDE (3 entities in total)
• 機能のキーワード: protein kinase, cell cycle, phosphorylation, cell division, mitosis, inhibition, transferase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 34398.02

構造登録者

Muckelbauer, J. (登録日: 2005-09-27, 公開日: 2005-10-11, 最終更新日: 2024-02-14)

• 主引用文献: Yue, E.W.,Higley, C.A.,Dimeo, S.V.,Carini, D.J.,Nugiel, D.A.,Benware, C.,Benfield, P.A.,Cox, S.,Burton, C.R.,Grafstrom, R.H.,Sharp, D.M.,Sisk, L.M.,Boylan, J.F.,Muckelbauer, J.K.,Smallwood, A.M.,Chen, H.,Chang, C.-H.,Seitz, S.P.,Trainor, G.L.; Synthesis and Evaluation of Indenopyrazoles as Cyclin-Dependent Kinase Inhibitors. 3. Structure Activity Relationships at C3; J.Med.Chem., 45:5233-5248, 2002; PubMed: 12431051; DOI: 10.1021/jm0201722

実験手法

X-RAY DIFFRACTION (1.85 Å)