2B37

Crystal structure of Mycobacterium tuberculosis enoyl reductase (InhA) inhibited by 5-octyl-2-phenoxyphenol

2B37 の概要

• エントリーDOI: 10.2210/pdb2b37/pdb
• 関連するPDBエントリー: 1BVR 1ENY 1ENZ 1P44 1P45 1ZID 2B35 2B36
• 分子名称: Enoyl-[acyl-carrier-protein] reductase [NADH], NICOTINAMIDE-ADENINE-DINUCLEOTIDE, 5-OCTYL-2-PHENOXYPHENOL, ... (4 entities in total)
• 機能のキーワード: enoyl reductase, oxidoreductase
• 由来する生物種: Mycobacterium tuberculosis
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 175906.07

構造登録者

Sullivan, T.J.,Truglio, J.J.,Novichenok, P.,Stratton, C.,Zhang, X.,Kaur, T.,Johnson, F.,Boyne, M.S.,Amin, A. (登録日: 2005-09-19, 公開日: 2006-03-07, 最終更新日: 2024-02-14)

• 主引用文献: Sullivan, T.J.,Truglio, J.J.,Boyne, M.E.,Novichenok, P.,Zhang, X.,Stratton, C.,Li, H.J.,Kaur, T.,Amin, A.,Johnson, F.,Slayden, R.A.,Kisker, C.,Tonge, P.J.; High Affinity InhA Inhibitors with Activity against Drug-Resistant Strains of Mycobacterium tuberculosis; ACS Chem.Biol., 1:43-53, 2006

実験手法

X-RAY DIFFRACTION (2.6 Å)