2AYR
A SERM Designed for the Treatment of Uterine Leiomyoma with Unique Tissue Specificity for Uterus and Ovaries in Rats
2AYR の概要
エントリーDOI | 10.2210/pdb2ayr/pdb |
分子名称 | Estrogen receptor, 6-(4-METHYLSULFONYL-PHENYL)-5-[4-(2-PIPERIDIN-1-YLETHOXY)PHENOXY]NAPHTHALEN-2-OL (3 entities in total) |
機能のキーワード | receptor, transcription, transcription regulation, ligand-binding, serm |
由来する生物種 | Homo sapiens (human) |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 28814.81 |
構造登録者 | Hummel, C.W.,Geiser, A.G.,Bryant, H.U.,Cohen, I.R.,Dally, R.D.,Fong, K.C.,Frank, S.A.,Hinklin, R.,Jones, S.A.,Lewis, G.,McCann, D.J.,Shepherd, T.A.,Tian, H.,Rudman, D.G.,Wallace, O.B.,Wang, Y.,Dodge, J.A. (登録日: 2005-09-07, 公開日: 2005-11-22, 最終更新日: 2023-08-23) |
主引用文献 | Hummel, C.W.,Geiser, A.G.,Bryant, H.U.,Cohen, I.R.,Dally, R.D.,Fong, K.C.,Frank, S.A.,Hinklin, R.,Jones, S.A.,Lewis, G.,McCann, D.J.,Rudman, D.G.,Shepherd, T.A.,Tian, H.,Wallace, O.B.,Wang, Y.,Dodge, J.A. A selective estrogen receptor modulator designed for the treatment of uterine leiomyoma with unique tissue specificity for uterus and ovaries in rats J.Med.Chem., 48:6772-6775, 2005 Cited by PubMed: 16250633DOI: 10.1021/jm050723z 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (1.9 Å) |
構造検証レポート
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