2AVQ

Kinetics, stability, and structural changes in high resolution crystal structures of HIV-1 protease with drug resistant mutations L24I, I50V, AND G73S

Summary for 2AVQ

Entry DOI	10.2210/pdb2avq/pdb
Related	2AVM 2AVO 2AVS 2AVV
Related PRD ID	PRD_000398
Descriptor	Pol polyprotein, DIMETHYL SULFOXIDE, GLYCEROL, ... (5 entities in total)
Functional Keywords	hiv-1 protease, drug resistant, substrate analog, non-active site mutants, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Human immunodeficiency virus type 1 (BH5 ISOLATE)
Cellular location	Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P04587
Total number of polymer chains	2
Total formula weight	22486.60
Authors	Liu, F.,Boross, P.I.,Wang, Y.F.,Tozser, J.,Louis, J.M.,Harrison, R.W.,Weber, I.T. (deposition date: 2005-08-30, release date: 2006-01-24, Last modification date: 2024-03-13)
Primary citation	Liu, F.,Boross, P.I.,Wang, Y.F.,Tozser, J.,Louis, J.M.,Harrison, R.W.,Weber, I.T. Kinetic, stability, and structural changes in high-resolution crystal structures of HIV-1 protease with drug-resistant mutations L24I, I50V, and G73S. J.Mol.Biol., 354:789-800, 2005 Cited by PubMed: 16277992 DOI: 10.1016/j.jmb.2005.09.095 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.3 Å)

Structure validation