2AVQ
Kinetics, stability, and structural changes in high resolution crystal structures of HIV-1 protease with drug resistant mutations L24I, I50V, AND G73S
Summary for 2AVQ
Entry DOI | 10.2210/pdb2avq/pdb |
Related | 2AVM 2AVO 2AVS 2AVV |
Related PRD ID | PRD_000398 |
Descriptor | Pol polyprotein, DIMETHYL SULFOXIDE, GLYCEROL, ... (5 entities in total) |
Functional Keywords | hiv-1 protease, drug resistant, substrate analog, non-active site mutants, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Human immunodeficiency virus type 1 (BH5 ISOLATE) |
Cellular location | Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P04587 |
Total number of polymer chains | 2 |
Total formula weight | 22486.60 |
Authors | Liu, F.,Boross, P.I.,Wang, Y.F.,Tozser, J.,Louis, J.M.,Harrison, R.W.,Weber, I.T. (deposition date: 2005-08-30, release date: 2006-01-24, Last modification date: 2024-03-13) |
Primary citation | Liu, F.,Boross, P.I.,Wang, Y.F.,Tozser, J.,Louis, J.M.,Harrison, R.W.,Weber, I.T. Kinetic, stability, and structural changes in high-resolution crystal structures of HIV-1 protease with drug-resistant mutations L24I, I50V, and G73S. J.Mol.Biol., 354:789-800, 2005 Cited by PubMed: 16277992DOI: 10.1016/j.jmb.2005.09.095 PDB entries with the same primary citation |
Experimental method |
Structure validation
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