2AVQ

Kinetics, stability, and structural changes in high resolution crystal structures of HIV-1 protease with drug resistant mutations L24I, I50V, AND G73S

2AVQ の概要

• エントリーDOI: 10.2210/pdb2avq/pdb
• 関連するPDBエントリー: 2AVM 2AVO 2AVS 2AVV
• 関連するBIRD辞書のPRD_ID: PRD_000398
• 分子名称: Pol polyprotein, DIMETHYL SULFOXIDE, GLYCEROL, ... (5 entities in total)
• 機能のキーワード: hiv-1 protease, drug resistant, substrate analog, non-active site mutants, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Human immunodeficiency virus type 1 (BH5 ISOLATE)
• 細胞内の位置: Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P04587
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 22486.60

構造登録者

Liu, F.,Boross, P.I.,Wang, Y.F.,Tozser, J.,Louis, J.M.,Harrison, R.W.,Weber, I.T. (登録日: 2005-08-30, 公開日: 2006-01-24, 最終更新日: 2024-03-13)

• 主引用文献: Liu, F.,Boross, P.I.,Wang, Y.F.,Tozser, J.,Louis, J.M.,Harrison, R.W.,Weber, I.T.; Kinetic, stability, and structural changes in high-resolution crystal structures of HIV-1 protease with drug-resistant mutations L24I, I50V, and G73S.; J.Mol.Biol., 354:789-800, 2005; PubMed: 16277992; DOI: 10.1016/j.jmb.2005.09.095

実験手法

X-RAY DIFFRACTION (1.3 Å)