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2AQU

Structure of HIV-1 protease bound to atazanavir

Summary for 2AQU
Entry DOI10.2210/pdb2aqu/pdb
DescriptorHIV-1 Protease, (3S,8S,9S,12S)-3,12-BIS(1,1-DIMETHYLETHYL)-8-HYDROXY-4,11-DIOXO-9-(PHENYLMETHYL)-6-[[4-(2-PYRIDINYL)PHENYL]METHYL]-2,5, 6,10,13-PENTAAZATETRADECANEDIOIC ACID DIMETHYL ESTER (3 entities in total)
Functional Keywordsaids, aspartyl protease, hydrolase
Biological sourceHuman immunodeficiency virus 1
Cellular locationMatrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03366
Total number of polymer chains2
Total formula weight22312.37
Authors
Primary citationClemente, J.C.,Coman, R.M.,Thiaville, M.M.,Janka, L.K.,Jeung, J.A.,Nukoolkarn, S.,Govindasamy, L.,Agbandje-McKenna, M.,McKenna, R.,Leelamanit, W.,Goodenow, M.M.,Dunn, B.M.
Analysis of HIV-1 CRF_01 A/E protease inhibitor resistance: structural determinants for maintaining sensitivity and developing resistance to atazanavir.
Biochemistry, 45:5468-5477, 2006
Cited by
PubMed: 16634628
DOI: 10.1021/bi051886s
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2 Å)
Structure validation

217705

數據於2024-03-27公開中

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