2AQU
Structure of HIV-1 protease bound to atazanavir
Summary for 2AQU
Entry DOI | 10.2210/pdb2aqu/pdb |
Descriptor | HIV-1 Protease, (3S,8S,9S,12S)-3,12-BIS(1,1-DIMETHYLETHYL)-8-HYDROXY-4,11-DIOXO-9-(PHENYLMETHYL)-6-[[4-(2-PYRIDINYL)PHENYL]METHYL]-2,5, 6,10,13-PENTAAZATETRADECANEDIOIC ACID DIMETHYL ESTER (3 entities in total) |
Functional Keywords | aids, aspartyl protease, hydrolase |
Biological source | Human immunodeficiency virus 1 |
Cellular location | Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03366 |
Total number of polymer chains | 2 |
Total formula weight | 22312.37 |
Authors | Clemente, J.C.,Coman, R.M.,Thiaville, M.M.,Janka, L.K.,Jeung, J.A.,Nukoolkarn, S.,Govindasamy, L.,Agbandje-McKenna, M.,McKenna, R.,Leelamanit, W.,Goodenow, M.M.,Dunn, B.M. (deposition date: 2005-08-18, release date: 2006-08-29, Last modification date: 2023-08-23) |
Primary citation | Clemente, J.C.,Coman, R.M.,Thiaville, M.M.,Janka, L.K.,Jeung, J.A.,Nukoolkarn, S.,Govindasamy, L.,Agbandje-McKenna, M.,McKenna, R.,Leelamanit, W.,Goodenow, M.M.,Dunn, B.M. Analysis of HIV-1 CRF_01 A/E protease inhibitor resistance: structural determinants for maintaining sensitivity and developing resistance to atazanavir. Biochemistry, 45:5468-5477, 2006 Cited by PubMed: 16634628DOI: 10.1021/bi051886s PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
Download full validation report