2AQU

Structure of HIV-1 protease bound to atazanavir

2AQU の概要

• エントリーDOI: 10.2210/pdb2aqu/pdb
• 分子名称: HIV-1 Protease, (3S,8S,9S,12S)-3,12-BIS(1,1-DIMETHYLETHYL)-8-HYDROXY-4,11-DIOXO-9-(PHENYLMETHYL)-6-[[4-(2-PYRIDINYL)PHENYL]METHYL]-2,5, 6,10,13-PENTAAZATETRADECANEDIOIC ACID DIMETHYL ESTER (3 entities in total)
• 機能のキーワード: aids, aspartyl protease, hydrolase
• 由来する生物種: Human immunodeficiency virus 1
• 細胞内の位置: Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03366
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 22312.37

構造登録者

Clemente, J.C.,Coman, R.M.,Thiaville, M.M.,Janka, L.K.,Jeung, J.A.,Nukoolkarn, S.,Govindasamy, L.,Agbandje-McKenna, M.,McKenna, R.,Leelamanit, W.,Goodenow, M.M.,Dunn, B.M. (登録日: 2005-08-18, 公開日: 2006-08-29, 最終更新日: 2023-08-23)

• 主引用文献: Clemente, J.C.,Coman, R.M.,Thiaville, M.M.,Janka, L.K.,Jeung, J.A.,Nukoolkarn, S.,Govindasamy, L.,Agbandje-McKenna, M.,McKenna, R.,Leelamanit, W.,Goodenow, M.M.,Dunn, B.M.; Analysis of HIV-1 CRF_01 A/E protease inhibitor resistance: structural determinants for maintaining sensitivity and developing resistance to atazanavir.; Biochemistry, 45:5468-5477, 2006; PubMed: 16634628; DOI: 10.1021/bi051886s

実験手法

X-RAY DIFFRACTION (2 Å)