2ANO

Crystal structure of E.coli dihydrofolate reductase in complex with NADPH and the inhibitor MS-SH08-17

2ANO の概要

• エントリーDOI: 10.2210/pdb2ano/pdb
• 分子名称: Dihydrofolate reductase, MANGANESE (II) ION, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (5 entities in total)
• 機能のキーワード: dhfr, protein inhibitor complex, oxidoreductase
• 由来する生物種: Escherichia coli
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 19096.97

構造登録者

Summerfield, R.L.,Daigle, D.M.,Mayer, S.,Jackson, S.G.,Organ, M.,Hughes, D.W.,Brown, E.D.,Junop, M.S. (登録日: 2005-08-11, 公開日: 2006-07-25, 最終更新日: 2024-02-14)

• 主引用文献: Summerfield, R.L.,Daigle, D.M.,Mayer, S.,Mallik, D.,Hughes, D.W.,Jackson, S.G.,Sulek, M.,Organ, M.G.,Brown, E.D.,Junop, M.S.; A 2.13 A Structure of E. coli Dihydrofolate Reductase Bound to a Novel Competitive Inhibitor Reveals a New Binding Surface Involving the M20 Loop Region; J.Med.Chem., 49:6977-6986, 2006; PubMed: 17125251; DOI: 10.1021/jm060570v

実験手法

X-RAY DIFFRACTION (2.68 Å)