2AFV

The Crystal Structure of Putative Precorrin Isomerase CbiC in Cobalamin Biosynthesis

2AFV の概要

• エントリーDOI: 10.2210/pdb2afv/pdb
• 関連するPDBエントリー: 2AFR
• 分子名称: cobalamin biosynthesis precorrin isomerase, CHLORIDE ION, HEXAETHYLENE GLYCOL, ... (5 entities in total)
• 機能のキーワード: isomerase
• 由来する生物種: Leptospira interrogans
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 52668.10

構造登録者

Xue, Y.,Wei, Z. (登録日: 2005-07-26, 公開日: 2006-04-04, 最終更新日: 2024-03-13)

主引用文献

Xue, Y.,Wei, Z.,Li, X.,Gong, W.
The crystal structure of putative precorrin isomerase CbiC in cobalamin biosynthesis
J.Struct.Biol., 153:307-311, 2006

PubMed Abstract: The leptospira cbiC encodes the enzyme catalyzing the methyl rearrangement reaction of the cobalamin biosynthesis pathway. The protein has been cloned and overexpressed as a His-tagged recombinant protein in Escherichia coli. The crystal structures have been solved in two crystal forms (P4(2)2(1)2 and P3(1)21) diffracting to 3.0 and 2.3A resolution, respectively. The structures are similar to the precorrin-8x methyl mutase (CobH), an enzyme of the aerobic pathway to vitamin B12.

PubMed: 16427313
DOI: 10.1016/j.jsb.2005.11.011

実験手法

X-RAY DIFFRACTION (3 Å)