2AFR

The Crystal Structure of Putative Precorrin Isomerase CbiC in Cobalamin Biosynthesis

Summary for 2AFR

Entry DOI	10.2210/pdb2afr/pdb
Related	2AFV
Descriptor	cobalamin biosynthesis precorrin isomerase (2 entities in total)
Functional Keywords	isomerase
Biological source	Leptospira interrogans
Total number of polymer chains	1
Total formula weight	25887.88
Authors	Xue, Y.,Wei, Z.,Li, X. (deposition date: 2005-07-26, release date: 2006-04-04, Last modification date: 2024-03-13)
Primary citation	Xue, Y.,Wei, Z.,Li, X.,Gong, W. The crystal structure of putative precorrin isomerase CbiC in cobalamin biosynthesis J.Struct.Biol., 153:307-311, 2006 Cited by PubMed Abstract: The leptospira cbiC encodes the enzyme catalyzing the methyl rearrangement reaction of the cobalamin biosynthesis pathway. The protein has been cloned and overexpressed as a His-tagged recombinant protein in Escherichia coli. The crystal structures have been solved in two crystal forms (P4(2)2(1)2 and P3(1)21) diffracting to 3.0 and 2.3A resolution, respectively. The structures are similar to the precorrin-8x methyl mutase (CobH), an enzyme of the aerobic pathway to vitamin B12. PubMed: 16427313 DOI: 10.1016/j.jsb.2005.11.011 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation