2AF6

Crystal structure of Mycobacterium tuberculosis Flavin dependent thymidylate synthase (Mtb ThyX) in the presence of co-factor FAD and substrate analog 5-Bromo-2'-Deoxyuridine-5'-Monophosphate (BrdUMP)

2AF6 の概要

• エントリーDOI: 10.2210/pdb2af6/pdb
• 分子名称: Thymidylate synthase thyX, IODIDE ION, FLAVIN-ADENINE DINUCLEOTIDE, ... (6 entities in total)
• 機能のキーワード: m.tuberculosis, thyx, fdts, tscp, flavin dependent thymidylate synthase, transferase
• 由来する生物種: Mycobacterium tuberculosis
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 243699.20

構造登録者

Sampathkumar, P.,Turley, S.,Ulmer, J.E.,Rhie, H.G.,Sibley, C.H.,Hol, W.G. (登録日: 2005-07-25, 公開日: 2005-10-04, 最終更新日: 2023-11-15)

• 主引用文献: Sampathkumar, P.,Turley, S.,Ulmer, J.E.,Rhie, H.G.,Sibley, C.H.,Hol, W.G.; Structure of the Mycobacterium tuberculosis Flavin Dependent Thymidylate Synthase (MtbThyX) at 2.0A Resolution.; J.Mol.Biol., 352:1091-1104, 2005; PubMed: 16139296; DOI: 10.1016/j.jmb.2005.07.071

実験手法

X-RAY DIFFRACTION (2.01 Å)