2ACY

ACYL-PHOSPHATASE (COMMON TYPE) FROM BOVINE TESTIS

2ACY の概要

• エントリーDOI: 10.2210/pdb2acy/pdb
• 分子名称: ACYLPHOSPHATASE, SULFATE ION, CHLORIDE ION, ... (4 entities in total)
• 機能のキーワード: acylphosphatase, phosphoric monoester hydrolase
• 由来する生物種: Bos taurus (cattle)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 11326.11

構造登録者

Thunnissen, M.M.G.M.,Nordlund, P. (登録日: 1996-11-08, 公開日: 1997-11-12, 最終更新日: 2024-02-14)

主引用文献

Thunnissen, M.M.,Taddei, N.,Liguri, G.,Ramponi, G.,Nordlund, P.
Crystal structure of common type acylphosphatase from bovine testis.
Structure, 5:69-79, 1997

PubMed Abstract: Acylphosphatase (ACP) is a low molecular weight phosphomonohydrolase catalyzing with high specificity the hydrolysis of the carboxyl-phosphate bond present in acylphosphates. The enzyme is thought to regulate metabolic processes in which acylphosphates are involved, such as glycolysis and the production of ribonucleotides. Furthermore the enzyme is capable of hydrolyzing the phospho-aspartyl intermediate formed during the action of membrane pumps such as (Ca2++Mg2+) ATPase. Although the tertiary structure of a muscle ACP has been determined by NMR spectroscopy, little is known about the catalytic mechanism of ACP and further structures might provide an increased understanding.

PubMed: 9016712
DOI: 10.1016/S0969-2126(97)00167-6

実験手法

X-RAY DIFFRACTION (1.8 Å)