2A4F

Synthesis and Activity of N-Axyl Azacyclic Urea HIV-1 Protease Inhibitors with High Potency Against Multiple Drug Resistant Viral Strains.

Summary for 2A4F

• Entry DOI: 10.2210/pdb2a4f/pdb
• Related: 1YT9
• Descriptor: Pol polyprotein, (5R,6R)-5-BENZYL-6-HYDROXY-2,4-BIS(4-HYDROXY-3-METHOXYBENZYL)-1-[3-(4-HYDROXYPHENYL)PROPANOYL]-1,2,4-TRIAZEPAN-3-ONE (3 entities in total)
• Functional Keywords: hiv protease, aza-cyclic urea, hydrolase
• Biological source: Human immunodeficiency virus 1
• Total number of polymer chains: 2
• Total formula weight: 22249.22

Authors

Zhao, C.,Sham, H.,Sun, M.,Lin, S.,Stoll, V.,Stewart, K.D.,Mo, H.,Vasavanonda, S.,Saldivar, A.,McDonald, E. (deposition date: 2005-06-28, release date: 2005-09-20, Last modification date: 2024-02-14)

• Primary citation: Zhao, C.,Sham, H.L.,Sun, M.,Stoll, V.S.,Stewart, K.D.,Lin, S.,Mo, H.,Vasavanonda, S.,Saldivar, A.,Park, C.,McDonald, E.J.,Marsh, K.C.,Klein, L.L.,Kempf, D.J.,Norbeck, D.W.; Synthesis and activity of N-acyl azacyclic urea HIV-1 protease inhibitors with high potency against multiple drug resistant viral strains; Bioorg.Med.Chem.Lett., 15:5499-5503, 2005; PubMed: 16203141; DOI: 10.1016/j.bmcl.2005.08.093

Experimental method

X-RAY DIFFRACTION (1.9 Å)