2A4F
Synthesis and Activity of N-Axyl Azacyclic Urea HIV-1 Protease Inhibitors with High Potency Against Multiple Drug Resistant Viral Strains.
Summary for 2A4F
Entry DOI | 10.2210/pdb2a4f/pdb |
Related | 1YT9 |
Descriptor | Pol polyprotein, (5R,6R)-5-BENZYL-6-HYDROXY-2,4-BIS(4-HYDROXY-3-METHOXYBENZYL)-1-[3-(4-HYDROXYPHENYL)PROPANOYL]-1,2,4-TRIAZEPAN-3-ONE (3 entities in total) |
Functional Keywords | hiv protease, aza-cyclic urea, hydrolase |
Biological source | Human immunodeficiency virus 1 |
Total number of polymer chains | 2 |
Total formula weight | 22249.22 |
Authors | Zhao, C.,Sham, H.,Sun, M.,Lin, S.,Stoll, V.,Stewart, K.D.,Mo, H.,Vasavanonda, S.,Saldivar, A.,McDonald, E. (deposition date: 2005-06-28, release date: 2005-09-20, Last modification date: 2024-02-14) |
Primary citation | Zhao, C.,Sham, H.L.,Sun, M.,Stoll, V.S.,Stewart, K.D.,Lin, S.,Mo, H.,Vasavanonda, S.,Saldivar, A.,Park, C.,McDonald, E.J.,Marsh, K.C.,Klein, L.L.,Kempf, D.J.,Norbeck, D.W. Synthesis and activity of N-acyl azacyclic urea HIV-1 protease inhibitors with high potency against multiple drug resistant viral strains Bioorg.Med.Chem.Lett., 15:5499-5503, 2005 Cited by PubMed: 16203141DOI: 10.1016/j.bmcl.2005.08.093 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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