298D

TARGETING THE MINOR GROOVE OF DNA: CRYSTAL STRUCTURES OF TWO COMPLEXES BETWEEN FURAN DERIVATIVES OF BERENIL AND THE DNA DODECAMER D(CGCGAATTCGCG)2

298D の概要

• エントリーDOI: 10.2210/pdb298d/pdb
• 分子名称: DNA (5'-D(*CP*GP*CP*GP*AP*AP*TP*TP*CP*GP*CP*G)-3'), 2,5-BIS{[4-(N-ISOPROPYL)DIAMINOMETHYL]PHENYL}FURAN (3 entities in total)
• 機能のキーワード: b-dna, double helix, complexed with drug, dna
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 7719.32

構造登録者

Trent, J.O.,Clark, G.R.,Kumar, A.,Wilson, W.D.,Boykin, D.W.,Hall, J.E.,Tidwell, R.R.,Blagburn, B.L.,Neidle, S. (登録日: 1996-10-10, 公開日: 1996-12-17, 最終更新日: 2024-04-03)

• 主引用文献: Trent, J.O.,Clark, G.R.,Kumar, A.,Wilson, W.D.,Boykin, D.W.,Hall, J.E.,Tidwell, R.R.,Blagburn, B.L.,Neidle, S.; Targeting the minor groove of DNA: crystal structures of two complexes between furan derivatives of berenil and the DNA dodecamer d(CGCGAATTCGCG)2.; J.Med.Chem., 39:4554-4562, 1996; PubMed: 8917643; DOI: 10.1021/jm9604484

実験手法

X-RAY DIFFRACTION (2.2 Å)