296D

SEQUENCE-DEPENDENT EFFECTS IN DRUG-DNA INTERACTION: THE CRYSTAL STRUCTURE OF HOECHST 33258 BOUND TO THE D(CGCAAATTTGCG)2 DUPLEX

Summary for 296D

• Entry DOI: 10.2210/pdb296d/pdb
• Descriptor: DNA (5'-D(*CP*GP*CP*AP*AP*AP*TP*TP*TP*GP*CP*G)-3'), 2'-(4-HYDROXYPHENYL)-5-(4-METHYL-1-PIPERAZINYL)-2,5'-BI-BENZIMIDAZOLE (3 entities in total)
• Functional Keywords: b-dna, double helix, complexed with drug, dna
• Total number of polymer chains: 2
• Total formula weight: 7749.31

Authors

Spink, N.,Brown, D.G.,Skelly, J.V.,Neidle, S. (deposition date: 1994-07-21, release date: 1996-12-04, Last modification date: 2024-02-14)

• Primary citation: Spink, N.,Brown, D.G.,Skelly, J.V.,Neidle, S.; Sequence-dependent effects in drug-DNA interaction: the crystal structure of Hoechst 33258 bound to the d(CGCAAATTTGCG)2 duplex.; Nucleic Acids Res., 22:1607-1612, 1994; PubMed: 7515488; DOI: 10.1093/nar/22.9.1607

Experimental method

X-RAY DIFFRACTION (2.25 Å)