292D

INTERACTION BETWEEN THE LEFT-HANDED Z-DNA AND POLYAMINE:THE CRYSTAL STRUCTURE OF THE D(CG)3 AND N-(2-AMINOETHYL)-1,4-DIAMINOBUTANE COMPLEX

Summary for 292D

• Entry DOI: 10.2210/pdb292d/pdb
• Descriptor: DNA (5'-D(*CP*GP*CP*GP*CP*G)-3'), 1-(AMINOETHYL)AMINO-4-AMINOBUTANE, MAGNESIUM ION, ... (5 entities in total)
• Functional Keywords: z-dna, double helix, complexed with n-(2-aminoethyl)-1, 4-diaminobutane, dna
• Total number of polymer chains: 2
• Total formula weight: 3847.53

Authors

Ohishi, H.,Kunisawa, S.,Van Der Marel, G.,Van Boom, J.H.,Rich, A.,Wang, A.H.-J.,Tomita, K.,Hakoshima, T. (deposition date: 1991-10-09, release date: 1996-12-02, Last modification date: 2024-04-03)

Primary citation

Ohishi, H.,Kunisawa, S.,van der Marel, G.,van Boom, J.H.,Rich, A.,Wang, A.H.,Tomita, K.,Hakoshima, T.
Interaction between the left-handed Z-DNA and polyamine. The crystal structure of the d(CG)3 and N-(2-aminoethyl)-1,4-diamino-butane complex.
FEBS Lett., 284:238-244, 1991

PubMed Abstract: The DNA fragment d(CG)3 was co-crystallized with N-(2-aminoethyl)-1,4-diaminobutane (PA(24], a chemically synthesized polyamine. The complex crystal contained one polyamine, 3 magnesium cations and one sodium cation per duplex of d(CG)3, and well diffracted the X-ray intensities up to 1.0 A resolution. The d(CG)3 took a left-handed Z-DNA conformation, and the PA(24) molecule electrostatically interacted with the phosphate groups of the d(CG)3 duplex.

PubMed: 2060642
DOI: 10.1016/0014-5793(91)80694-X

Experimental method

X-RAY DIFFRACTION (1 Å)