289D

TARGETING THE MINOR GROOVE OF DNA: CRYSTAL STRUCTURES OF TWO COMPLEXES BETWEEN FURAN DERIVATIVES OF BERENIL AND THE DNA DODECAMER D(CGCGAATTCGCG)2

Summary for 289D

DescriptorDNA (5'-R(*CP*GP*CP*GP*AP*AP*TP*TP*CP*GP*CP*G)-3'), 2,5-BIS{[4-(N-CYCLOPROPYLDIAMINOMETHYL)PHENYL]}FURAN (3 entities in total)
Functional Keywordsb-dna, double helix, complexed with drug, dna
Total number of polymer chains2
Total molecular weight7715.29
Authors
Trent, J.O.,Clark, G.R.,Kumar, A.,Wilson, W.D.,Boykin, D.W.,Hall, J.E.,Tidwell, R.R.,Blagburn, B.L.,Neidle, S. (deposition date: 1996-10-10, release date: 1996-12-17, Last modification date: 2011-07-13)
Primary citation
Trent, J.O.,Clark, G.R.,Kumar, A.,Wilson, W.D.,Boykin, D.W.,Hall, J.E.,Tidwell, R.R.,Blagburn, B.L.,Neidle, S.
Targeting the minor groove of DNA: crystal structures of two complexes between furan derivatives of berenil and the DNA dodecamer d(CGCGAATTCGCG)2.
J.Med.Chem., 39:4554-4562, 1996
PubMed: 8917643 (PDB entries with the same primary citation)
DOI: 10.1021/jm9604484
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.2 Å)
?

Structure validation

ClashscoreRSRZ outliers180MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 289d
no rotation
Molmil generated image of 289d
rotated about x axis by 90°
Molmil generated image of 289d
rotated about y axis by 90°