248D

CRYSTAL STRUCTURES OF AN A-FORM DUPLEX WITH SINGLE-ADENOSINE BULGES AND A CONFORMATIONAL BASIS FOR SITE SPECIFIC RNA SELF-CLEAVAGE

248D の概要

• エントリーDOI: 10.2210/pdb248d/pdb
• 分子名称: DNA/RNA (5'-R(*GP*CP*GP*)-D(*AP*TP*AP*TP*AP*)-R(*CP*GP*C)-3'), ORTHORHOMBIC, SPERMINE (3 entities in total)
• 機能のキーワード: a-dna/rna, double helix, bulges, dna-rna complex, dna/rna
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 3858.89

構造登録者

Portmann, S.,Grimm, S.,Workman, C.,Usman, N.,Egli, M. (登録日: 1996-02-02, 公開日: 1996-03-08, 最終更新日: 2024-02-14)

主引用文献

Portmann, S.,Grimm, S.,Workman, C.,Usman, N.,Egli, M.
Crystal structures of an A-form duplex with single-adenosine bulges and a conformational basis for site-specific RNA self-cleavage.
Chem.Biol., 3:173-184, 1996

PubMed Abstract: Bulged nucleotides are common secondary structural motifs in RNA molecules and are often involved in RNA-RNA and RNA-protein interactions. RNA is selectively cleaved at bulge sites (when compared to other sites within stems) in the presence of divalent metal cations. The effects of bulge nucleotides on duplex stability and topology have been extensively investigated, but no detailed X-ray structures of bulge-containing RNA fragments have been available.

PubMed: 8807843
DOI: 10.1016/S1074-5521(96)90260-4

実験手法

X-RAY DIFFRACTION (1.83 Å)