23MC

Crystal structure of SARS-CoV-2 main protease M49I mutant in complex with leritrelvir

23MC の概要

• エントリーDOI: 10.2210/pdb23mc/pdb
• 関連するPDBエントリー: 8ign
• 分子名称: 3C-like proteinase nsp5, Leritrelvir bound form, GLYCEROL, ... (4 entities in total)
• 機能のキーワード: sars-cov-2, nsp5, main protease, coronavirus, protease inhibitor, alpha-ketoamide inhibitor, peptidomimetic inhibitor, viral protein
• 由来する生物種: Severe acute respiratory syndrome coronavirus 2
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 70542.37

構造登録者

Huang, X.,Li, Q.,Yang, Z.,Zhong, N.,Xiong, X. (登録日: 2026-02-11, 公開日: 2026-06-03, 最終更新日: 2026-06-24)

• 主引用文献: Huang, X.,Kuzmic, P.,Zhang, S.,Ramos-Guzman, C.A.,Chen, X.,Gui, J.,Li, Q.,Yan, S.,Zou, B.,Niu, C.,Zhao, Y.,Lin, H.,Wang, N.,Chen, J.,Chen, X.,Spencer, J.,Mulholland, A.J.,Chen, J.,Zhong, N.,Yang, Z.,Xiong, X.; Enhanced Target Binding by Leritrelvir Restores Dimerization of M^pro Mutants and Mitigates Drug Resistance; Biorxiv, 2026; DOI: 10.64898/2026.06.09.730104

実験手法

X-RAY DIFFRACTION (1.87 Å)