238D

CRYSTAL STRUCTURE OF THE DNA DECAMER D(AGG(BR)CATGCCT): COMPARISON WITH D(AGGCATGCCT) AND IMPLICATIONS FOR COBALT HEXAMMINE BINDING TO DNA

238D の概要

• エントリーDOI: 10.2210/pdb238d/pdb
• 分子名称: DNA (5'-D(*AP*GP*GP*(CBR)P*AP*TP*GP*CP*CP*T)-3') (2 entities in total)
• 機能のキーワード: a-dna, double helix, flipped-out bases, base triplet, dna
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 3123.90

構造登録者

Nunn, C.M. (登録日: 1995-11-02, 公開日: 1996-01-30, 最終更新日: 2024-02-14)

主引用文献

Nunn, C.M.
Crystal structure of d(AGGBrCATGCCT): implications for cobalt hexammine binding to DNA
J.Biomol.Struct.Dyn., 14:49-56, 1996

PubMed Abstract: The crystal structure of the DNA decamer d(AGGBrCATGCCT) has been determined to a resolution of 2.0 A and R factor of 19.6%. Crystals of d(AGGBrCATGCCT) were grown in the presence of cobalt hexammine but no cobalt hexammine ions are bound to the DNA structure. This contrasts with the recently determined crystal structure of d(AGGCATGCCT) which has a similar DNA conformation and cobalt hexammine ions bound directly to the DNA. Comparison with the structure of d(AGGCATGCCT) and appreciation of the crystal packing of this sequence leads to an understanding of how cobalt hexammine binding to DNA occurs and its role in determining DNA conformation.

PubMed: 8877561

実験手法

X-RAY DIFFRACTION (2 Å)