227D

A CRYSTALLOGRAPHIC AND SPECTROSCOPIC STUDY OF THE COMPLEX BETWEEN D(CGCGAATTCGCG)2 AND 2,5-BIS(4-GUANYLPHENYL)FURAN, AN ANALOGUE OF BERENIL. STRUCTURAL ORIGINS OF ENHANCED DNA-BINDING AFFINITY

Summary for 227D

DescriptorDNA (5'-D(*CP*GP*CP*GP*AP*AP*TP*TP*CP*GP*CP*G)-3'), 2,5-BIS(4-GUANYLPHENYL)FURAN (3 entities in total)
Functional Keywordsb-dna, double helix, complexed with drug, dna
Total number of polymer chains2
Total molecular weight7633.15
Authors
Laughton, C.A.,Tanious, F.,Nunn, C.M.,Boykin, D.W.,Wilson, W.D.,Neidle, S. (deposition date: 1995-08-08, release date: 1995-11-11, Last modification date: 2011-07-13)
Primary citation
Laughton, C.A.,Tanious, F.,Nunn, C.M.,Boykin, D.W.,Wilson, W.D.,Neidle, S.
A crystallographic and spectroscopic study of the complex between d(CGCGAATTCGCG)2 and 2,5-bis(4-guanylphenyl)furan, an analogue of berenil. Structural origins of enhanced DNA-binding affinity.
Biochemistry, 35:5655-5661, 1996
PubMed: 8639524 (PDB entries with the same primary citation)
DOI: 10.1021/bi952162r
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.2 Å)
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Structure validation

ClashscoreRSRZ outliers50MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 227d
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Molmil generated image of 227d
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Molmil generated image of 227d
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