227D

A CRYSTALLOGRAPHIC AND SPECTROSCOPIC STUDY OF THE COMPLEX BETWEEN D(CGCGAATTCGCG)2 AND 2,5-BIS(4-GUANYLPHENYL)FURAN, AN ANALOGUE OF BERENIL. STRUCTURAL ORIGINS OF ENHANCED DNA-BINDING AFFINITY

227D の概要

• エントリーDOI: 10.2210/pdb227d/pdb
• 分子名称: DNA (5'-D(*CP*GP*CP*GP*AP*AP*TP*TP*CP*GP*CP*G)-3'), 2,5-BIS(4-GUANYLPHENYL)FURAN (3 entities in total)
• 機能のキーワード: b-dna, double helix, complexed with drug, dna
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 7633.15

構造登録者

Laughton, C.A.,Tanious, F.,Nunn, C.M.,Boykin, D.W.,Wilson, W.D.,Neidle, S. (登録日: 1995-08-08, 公開日: 1995-11-11, 最終更新日: 2024-02-14)

• 主引用文献: Laughton, C.A.,Tanious, F.,Nunn, C.M.,Boykin, D.W.,Wilson, W.D.,Neidle, S.; A crystallographic and spectroscopic study of the complex between d(CGCGAATTCGCG)2 and 2,5-bis(4-guanylphenyl)furan, an analogue of berenil. Structural origins of enhanced DNA-binding affinity.; Biochemistry, 35:5655-5661, 1996; PubMed: 8639524; DOI: 10.1021/bi952162r

実験手法

X-RAY DIFFRACTION (2.2 Å)