211D

THE CRYSTAL AND MOLECULAR STRUCTURE OF A NEW Z-DNA CRYSTAL FORM: D[CGT(2-NH2-A) CG] AND ITS PLATINATED DERIVATIVE

211D の概要

• エントリーDOI: 10.2210/pdb211d/pdb
• 分子名称: DNA (5'-D(*CP*GP*TP*(1AP)P*CP*(PT(NH3)3)G)-3'), PLATINUM TRIAMINE ION, SPERMINE, ... (4 entities in total)
• 機能のキーワード: z-dna, double helix, modified, dna
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 2272.74

構造登録者

Parkinson, G.N.,Arvantis, G.M.,Lessinger, L.,Ginell, S.L.,Jones, R.,Gaffney, B.,Berman, H.M. (登録日: 1995-06-13, 公開日: 1996-03-22, 最終更新日: 2024-02-14)

主引用文献

Parkinson, G.N.,Arvanitis, G.M.,Lessinger, L.,Ginell, S.L.,Jones, R.,Gaffney, B.,Berman, H.M.
Crystal and molecular structure of a new Z-DNA crystal form: d[CGT(2-NH2-A)CG] and its platinated derivative.
Biochemistry, 34:15487-15495, 1995

PubMed Abstract: The three-dimensional structure of d[CGTA'CG], where A' = [2-NH2-A], was determined to atomic (1.35 A) resolution by single isomorphous replacement. The d[CGTA'CG] hexamer crystallizes in space group P3221, and is not isomorphous with other DNA hexanucleotides. Despite completely different crystal packing, the essential characteristics of the Z-DNA conformation are maintained. The structure was determined by single isomorphous replacement using a triammine platinum fragment. Thus, this study also demonstrates, for the first time, the feasibility of the use of this reagent for the direct phasing of DNA crystal structures.

PubMed: 7492550
DOI: 10.1021/bi00047a014

実験手法

X-RAY DIFFRACTION (1.6 Å)