200D

STABLE LOOP IN THE CRYSTAL STRUCTURE OF THE INTERCALATED FOUR-STRANDED CYTOSINE-RICH METAZOAN TELOMERE

200D の概要

• エントリーDOI: 10.2210/pdb200d/pdb
• 分子名称: DNA (5'-D(*TP*AP*AP*CP*CP*C)-3') (2 entities in total)
• 機能のキーワード: u-dna, quadruple helix, tetraplex, base intercalated, loop, dna
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 3506.39

構造登録者

Kang, C.,Berger, I.,Lockshin, C.,Ratliff, R.,Moyzis, R.,Rich, A. (登録日: 1995-02-16, 公開日: 1995-07-31, 最終更新日: 2024-02-14)

主引用文献

Kang, C.,Berger, I.,Lockshin, C.,Ratliff, R.,Moyzis, R.,Rich, A.
Stable loop in the crystal structure of the intercalated four-stranded cytosine-rich metazoan telomere.
Proc.Natl.Acad.Sci.USA, 92:3874-3878, 1995

PubMed Abstract: In most metazoans, the telomeric cytosine-rich strand repeating sequence is d(TAACCC). The crystal structure of this sequence was solved to 1.9-A resolution. Four strands associate via the cytosine-containing parts to form a four-stranded intercalated structure held together by C.C+ hydrogen bonds. The base-paired strands are parallel to each other, and the two duplexes are intercalated into each other in opposite orientations. One TAA end forms a highly stabilized loop with the 5' thymine Hoogsteen-base-paired to the third adenine. The 5' end of this loop is in close proximity to the 3' end of one of the other intercalated cytosine strands. Instead of being entirely in a DNA duplex, this structure suggests the possibility of an alternative conformation for the cytosine-rich telomere strands.

PubMed: 7731999
DOI: 10.1073/pnas.92.9.3874

実験手法

X-RAY DIFFRACTION (1.85 Å)