1ZTL

Crystal Structure of the Catalytic Domain of Coagulation Factor XI in Complex with N-[4-Guanidino-1-(thiazole-2-carbonyl)-butyl]-2-{6-oxo-5-[(quinolin-8-ylmethyl)-amino]-2-m-tolyl-6H-pyrimidin-1-yl}-acetamide

Summary for 1ZTL

• Entry DOI: 10.2210/pdb1ztl/pdb
• Descriptor: Coagulation factor XI, SULFATE ION, N-[4-GUANIDINO-1-(THIAZOLE-2-CARBONYL)-BUTYL]-2-{6-OXO-5-[(QUINOLIN-8-YLMETHYL)-AMINO]-2-M-TOLYL-6H-PYRIMIDIN-1-YL}-ACETAMIDE, ... (4 entities in total)
• Functional Keywords: fxia, inhibitors, hydrolase
• Biological source: Homo sapiens (human)
• Cellular location: Secreted: P03951
• Total number of polymer chains: 1
• Total formula weight: 27568.22

Authors

Nagafuji, P.,Jin, L.,Rynkiewicz, M.,Quinn, J.,Bibbins, F.,Meyers, H.,Babine, R.,Strickler, J.E.,Abdel-Meguid, S.S. (deposition date: 2005-05-27, release date: 2006-05-09, Last modification date: 2023-08-23)

• Primary citation: Nagafuji, P.,Jin, L.,Rynkiewicz, M.,Quinn, J.,Bibbins, F.,Meyers, H.,Babine, R.,Strickler, J.E.,Abdel-Meguid, S.S.; Pyrimidinone Inhibitors of a Thrombolytic Protease; To be Published,

Experimental method

X-RAY DIFFRACTION (2.6 Å)