1ZTL

Crystal Structure of the Catalytic Domain of Coagulation Factor XI in Complex with N-[4-Guanidino-1-(thiazole-2-carbonyl)-butyl]-2-{6-oxo-5-[(quinolin-8-ylmethyl)-amino]-2-m-tolyl-6H-pyrimidin-1-yl}-acetamide

1ZTL の概要

• エントリーDOI: 10.2210/pdb1ztl/pdb
• 分子名称: Coagulation factor XI, SULFATE ION, N-[4-GUANIDINO-1-(THIAZOLE-2-CARBONYL)-BUTYL]-2-{6-OXO-5-[(QUINOLIN-8-YLMETHYL)-AMINO]-2-M-TOLYL-6H-PYRIMIDIN-1-YL}-ACETAMIDE, ... (4 entities in total)
• 機能のキーワード: fxia, inhibitors, hydrolase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Secreted: P03951
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 27568.22

構造登録者

Nagafuji, P.,Jin, L.,Rynkiewicz, M.,Quinn, J.,Bibbins, F.,Meyers, H.,Babine, R.,Strickler, J.E.,Abdel-Meguid, S.S. (登録日: 2005-05-27, 公開日: 2006-05-09, 最終更新日: 2023-08-23)

• 主引用文献: Nagafuji, P.,Jin, L.,Rynkiewicz, M.,Quinn, J.,Bibbins, F.,Meyers, H.,Babine, R.,Strickler, J.E.,Abdel-Meguid, S.S.; Pyrimidinone Inhibitors of a Thrombolytic Protease; To be Published,

実験手法

X-RAY DIFFRACTION (2.6 Å)