1ZSK
Crystal Structure of the Catalytic Domain of Coagulation Factor XI in Complex with 6-Carbamimidoyl-4-(3-hydroxy-2-methyl-benzoylamino)-naphthalene-2-carboxylic acid methyl ester
Summary for 1ZSK
Entry DOI | 10.2210/pdb1zsk/pdb |
Related | 1ZSJ |
Descriptor | Coagulation factor XI, SULFATE ION, BICARBONATE ION, ... (5 entities in total) |
Functional Keywords | fxia, inhibitors, hydrolase |
Biological source | Homo sapiens (human) |
Cellular location | Secreted: P03951 |
Total number of polymer chains | 1 |
Total formula weight | 27382.90 |
Authors | Guo, Z.,Bannister, T.,Noll, R.,Jin, L.,Rynkiewicz, M.,Bibbins, F.,Magee, S.,Gorga, J.,Babine, R.E.,Strickler, J.E.,Meyers, H.V.,Abdel-Meguid, S.S. (deposition date: 2005-05-24, release date: 2006-05-23, Last modification date: 2023-08-23) |
Primary citation | Guo, Z.,Bannister, T.,Noll, R.,Jin, L.,Rynkiewicz, M.,Bibbins, F.,Magee, S.,Gorga, J.,Babine, R.E.,Strickler, J.E.,Meyers, H.V.,Abdel-Meguid, S.S. Synthesis and Optimization of Potent and Selective Inhibitors for Human Factor XIa: Substituted Naphthamidine Series To be Published, |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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