1ZSJ
Crystal Structure of the Catalytic Domain of Coagulation Factor XI in complex with N-(7-Carbamimidoyl-naphthalen-1-yl)-3-hydroxy-2-methyl-benzamide
Summary for 1ZSJ
Entry DOI | 10.2210/pdb1zsj/pdb |
Related | 1ZSK |
Descriptor | Coagulation factor XI, SULFATE ION, BICARBONATE ION, ... (5 entities in total) |
Functional Keywords | fxia, inhibitors, hydrolase |
Biological source | Homo sapiens (human) |
Cellular location | Secreted: P03951 |
Total number of polymer chains | 1 |
Total formula weight | 27228.81 |
Authors | Guo, Z.,Bannister, T.,Noll, R.,Jin, L.,Rynkiewicz, M.,Bibbins, F.,Magee, S.,Gorga, J.,Babine, R.E.,Strickler, J.E.,Meyers, H.V.,Abdel-Meguid, S.S. (deposition date: 2005-05-24, release date: 2006-05-23, Last modification date: 2023-08-23) |
Primary citation | Guo, Z.,Bannister, T.,Noll, R.,Jin, L.,Rynkiewicz, M.,Bibbins, F.,Magee, S.,Gorga, J.,Babine, R.E.,Strickler, J.E.,Meyers, H.V.,Abdel-Meguid, S.S. Synthesis and Optimization of Potent and Selective Inhibitors for Human Factor XIa: Substituted Naphthamidine Series To be Published, |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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