1ZS0

Crystal structure of the complex between MMP-8 and a phosphonate inhibitor (S-enantiomer)

Summary for 1ZS0

DescriptorNeutrophil collagenase, CALCIUM ION, ZINC ION, ... (6 entities in total)
Functional Keywordsphosphonic inhibitor, sulphonamide junction, stereoselective inhibition, hydrolase
Biological sourceHomo sapiens (human)
Cellular locationCytoplasmic granule P22894
Total number of polymer chains1
Total molecular weight18917.35
Authors
Pochetti, G.,Gavuzzo, E.,Campestre, C.,Agamennone, M.,Tortorella, P.,Consalvi, V.,Gallina, C.,Hiller, O.,Tschesche, H.,Tucker, P.A.,Mazza, F. (deposition date: 2005-05-23, release date: 2006-05-02, Last modification date: 2018-01-24)
Primary citation
Pochetti, G.,Gavuzzo, E.,Campestre, C.,Agamennone, M.,Tortorella, P.,Consalvi, V.,Gallina, C.,Hiller, O.,Tschesche, H.,Tucker, P.A.,Mazza, F.
Structural insight into the stereoselective inhibition of MMP-8 by enantiomeric sulfonamide phosphonates.
J.Med.Chem., 49:923-931, 2006
PubMed: 16451058 (PDB entries with the same primary citation)
DOI: 10.1021/jm050787+
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.56 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.2311703.8%9.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution