1ZS0

Crystal structure of the complex between MMP-8 and a phosphonate inhibitor (S-enantiomer)

1ZS0 の概要

• エントリーDOI: 10.2210/pdb1zs0/pdb
• 分子名称: Neutrophil collagenase, CALCIUM ION, ZINC ION, ... (6 entities in total)
• 機能のキーワード: phosphonic inhibitor, sulphonamide junction, stereoselective inhibition, hydrolase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasmic granule: P22894
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 18917.35

構造登録者

Pochetti, G.,Gavuzzo, E.,Campestre, C.,Agamennone, M.,Tortorella, P.,Consalvi, V.,Gallina, C.,Hiller, O.,Tschesche, H.,Tucker, P.A.,Mazza, F. (登録日: 2005-05-23, 公開日: 2006-05-02, 最終更新日: 2023-08-23)

• 主引用文献: Pochetti, G.,Gavuzzo, E.,Campestre, C.,Agamennone, M.,Tortorella, P.,Consalvi, V.,Gallina, C.,Hiller, O.,Tschesche, H.,Tucker, P.A.,Mazza, F.; Structural insight into the stereoselective inhibition of MMP-8 by enantiomeric sulfonamide phosphonates.; J.Med.Chem., 49:923-931, 2006; PubMed: 16451058; DOI: 10.1021/jm050787+

実験手法